Nicotinamide or Vitamin B3, delivered at high doses, increases a thousandfold the body’s ability to destroy staph infections increasingly resistant to antibiotics, according to a study conducted in the United States.
The research, conducted on laboratory animals and human blood revealed that high doses of vitamin A thousand times increase in the immune response against these bacteria.
The study, made by scientists at Cedars-Sinai Medical Center, Linus Pauling Institute of Oregon State University, the University of California Los Angeles (UCLA) and other institutions, is published in the Journal of Clinical Investigation.
The researchers found that the supply of therapeutic doses of nicotinamide increased the number and effectiveness of neutrophils, specialized white blood cells that kill and devour harmful bacteria.
The finding may open new avenues to combat the increasing number of antibiotic-resistant bacteria, especially the “Staphylococcus aureus” cause most hospital infections.
“This is potentially significant, although we conduct human studies,” said one of the lead authors, Adrian Gombart Linus Pauling Institute.
According to the scientist, the vitamin could be a new method to treat staph infections in combination with existing antibiotics, as it stimulates the immune system.
In the experiment, nicotinamide was supplied in doses much higher than those that provide any normal diet, although in amounts that have been used safely in humans for other medical purposes.
When vitamin B3 in human blood was injected at this dose, the infection disappeared within hours, the study found.
However, Gombart warns that there is no evidence that a normal diet or vitamin B3 supplements have a beneficial effect in the prevention or treatment of a bacterial infection, so that “people should not start taking high doses of this Vitamin “.
The main natural sources are meat nicotinamide liver and other organs, eggs, fish, peanuts, legumes, grains (corn), milk and artichokes.
According to another author, George Liu, an expert in infectious diseases at Cedars-Sinai, the vitamin is “surprisingly effective” against one of the main threats facing public health today and can help reduce our reliance on antibiotics .
In the 1950s, with the introduction of penicillin and sulfonamides, streptococci, staphylococci were displaced by the agent and hospital infection 1959, methicillin shown (a semisynthetic penicillin), 60% of the strains and were resistant to penicillin.