Scientists at the University of Michigan (United States) have managed to reproduce how bacterial infections are resistant to antibiotics in an experiment that can help treat these diseases, the bank.
The team, consisting of physicians, engineers and mathematicians devised a device that simulates the flow of blood, which showed that bacteria can become resistant to antibiotics lumps in no time, even in a liquid such as blood flowing.
The apparatus reproduces the force and turbulence of blood flow and added to the liquid used for the experiment a strain of Klebsiella pneumoniae bacteria, which is one of the most common sources of infection of the bloodstream.
In two hours just found that accumulations or lumps formed of ten to twenty bacteria in the fluid flow about the same time it takes to develop infections in human patients.
The researchers also showed that these lumps are formed only when certain molecules are present in the carbohydrate sticky surface of the bacterium.
The lumps were added persisted even when two different types of antibiotics, which indicates that the grouped kept floating bacteria protects against the effects of medicines.
When researchers injected mice lumps in accumulations of bacteria remained intact even after many crossings complete bloodstream.
Any lumps, about the size of a red blood cell, survived the filtration that normally occurs in smaller blood vessels and that defends the body against invaders.
“This study shows that if you let grow bacterial pathogens in fluid dynamic environments such as those found in the bloodstream, they begin to adopt the features that you see in patients,” he said in a statement John Younger team manager who for years has studied the origins of bloodstream infections.
Some bloodstream infections (sepsis) start with cuts and wounds, also the damage to the gums when brushing her teeth may be the source.
Most people combat such infections with natural immunity, but the elderly, cancer patients on dialysis and those who have undergone surgery are much more likely to develop aggressive infections, experts say.
Also warn that the odds of serious infection increase when someone is exposed to a source of infection, as a central pipe catheter that stays in place for days or weeks which gives tens of thousands of bacteria the way for enter the bloodstream.
So “The better we can reproduce what bacteria are experienced when patients better understand what they do and why they can cause overwhelming infection throughout an organization,” said Younger, professor in the Department of Emergency Medicine at School of Medicine, University of Michigan.
“Once we know how to behave intelligently we can work on how to effectively filter them and remove them from the bloodstream,” he added.