Spanish scientists have found that a bone protein, also present in the brain can start burning body fat, a breakthrough that will help create anti-obesity drugs.
The human body has two types of fat: white, the cause of overweight and obesity, and brown, which acts as a heating boiler human and starts burning calories and produces body heat.
Until recently it was thought that only babies and some mammals brown adipose tissue was available, but recent research has shown that these fats is also in adult humans.
These fats are therefore an important therapeutic target in treating and combating obesity developed by scientists at the Center of Biomedical Research Network Pathophysiology of Obesity and Nutrition (CIBERobn), authors of the discovery.
The researchers from the Universities of Barcelona and Santiago de Compostela, have shown that injecting a protein supplement 8B bone brown fat is activated and starts the burning white fat or calories.
The research, led by Dr. Francesc Villarroya (Universidad de Barcelona) and Dr. Miguel Lopez (University of Santiago de Compostela), has enjoyed the participation of scientists from Iowa (USA), Stockholm (Sweden) and Cambridge ( UK) and published in the journal Cell, specializing in biomedicine and molecular biology.
To carry out the study, the researchers injected mice “extras” of bone morphogenetic protein 8B (BMP8B), a substance linked to growth factors responsible for the formation of bones, cartilage and connective tissues.
By increasing the levels of this protein in the hypothalamus in the brain of experimental mice, the scientists saw that this was sufficient to increase “in a very powerful” body temperature of animals and thus burning fat.
By contrast, mice lacking BMP8B “were markedly obese, despite having reduced food intake,” which is due to fact that they had “a reduced ability to burn fat in brown adipose tissue,” says Lopez.